Endocrine Disruptor (ED)

Endocrine disruptors (EDs) are substances that interfere with the hormonal systems of living organisms. Under REACH Article 57(f), substances identified as having endocrine-disrupting properties with probable serious effects on human health or the environment — and for which there is scientific evidence of probable serious effects — may be identified as SVHCs on the basis of ‘equivalent concern.’ ECHA’s Integrated Regulatory Strategy identifies EDs as a priority substance group for restriction and SVHC identification under the REACH Recast.

REACH Regulation (EC) No 1907/2006, Article 57(f); ECHA Integrated Regulatory Strategy 2025; REACH Recast proposals.

The category of ED-based SVHCs is expanding. Companies using substances with known or suspected ED properties (e.g., bisphenol A, certain PFAS, some UV stabilisers) should anticipate Candidate List additions based on ED criteria. The REACH Recast is expected to formalise ED and PMT/vPvM as priority substance categories with streamlined restriction pathways, accelerating regulatory action on these substance groups.