Toxic (PBT Criterion)

The third PBT criterion. A chemical is toxic when it causes adverse health effects: carcinogenicity, reproductive toxicity, developmental toxicity, endocrine disruption, neurotoxicity, or aquatic toxicity. All five TSCA PBT chemicals meet this criterion.

TSCA § 6(h); EPA 2018 Assessments.

EPA does not need to quantify a specific risk level—demonstrating toxicity combined with persistence and bioaccumulation is sufficient for expedited action. PBT chemicals are regulated based on inherent hazard properties.

PIP (3:1) exhibits reproductive and developmental toxicity, qualifying it for Section 6(h) restriction.