Substance Evaluation

Substance evaluation under REACH Article 44–48 is an in-depth assessment by a Member State Competent Authority (MSCA) to clarify whether a substance poses a risk to human health or the environment. Substances are selected for evaluation based on ECHA’s Community Rolling Action Plan (CoRAP). Following substance evaluation, the MSCA may request additional information from registrants or recommend follow-up regulatory action (restriction, authorisation, or harmonised classification).

REACH Regulation (EC) No 1907/2006, Articles 44–48; ECHA CoRAP.

Companies whose registered substances appear on the CoRAP should monitor MSCA evaluation progress and be prepared to respond to information requests within the defined deadlines. Substance evaluation outcomes can trigger SVHC identification, Annex XIV listing, or restriction proposals. Proactive engagement with the evaluating MSCA — providing additional data and exposure information — can positively influence the regulatory outcome.