C
CMR Substance
Definition
A CMR substance is a chemical classified as Carcinogenic, Mutagenic, or Toxic for Reproduction under CLP Regulation (EC) No 1272/2008. Categories: 1A (known CMR effect on humans), 1B (presumed CMR effect, primarily based on animal evidence), and 2 (suspected CMR). Under REACH Article 57(a)(b)(c), substances classified as CMR Cat 1A/1B qualify as SVHCs and can be added to the Candidate List and subsequently to the Authorisation List (Annex XIV). Commission Regulation (EU) 2025/1731 (effective 1 September 2025) added newly classified CMR 1B substances including TBBPA, N,N-dimethyl-p-toluidine, and others to Annex XVII Appendices.
Source
REACH Regulation (EC) No 1907/2006, Article 57(a)(b)(c); CLP Regulation (EC) No 1272/2008, Annex VI; Commission Regulation (EU) 2025/1731.
Practical Explanation (Compliance Context)
Tracking CLP harmonised classification updates (ATPs) is critical because a new CMR 1A/1B classification automatically opens the pathway to SVHC identification and Annex XIV listing. Supply chain managers should monitor ATP publications and assess whether substances in their processes or products are subject to revised CMR classifications, particularly for Annex XVII supply-to-the-public restrictions.